Research

Laboratory of SIDS Research

Hannah C. Kinney, MD, Director, and Robin L. Haynes, PhD, Associate Director,

Research Registry of Robert’s Program

Director, Richard D. Goldstein, MD, Associate Director, Hannah C. Kinney, MD

Boston Children’s Hospital

Harvard Medical School

Boston, MA 02115

December 5 2016

 

  1. Background

 

 

 

  1. Ongoing Laboratory Research Projects in the Laboratory

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. Research in Robert’s Program on Sudden Unexpected Death in Pediatrics

 

 

 

 

 

 


 

 

 

SIDS-Related Publications  Since 2014

 

Original Reports

 

  1. Rognum IJ, Tran H, Haas EA, Hyland K, Paterson DS, Haynes RL, Broadbelt KG, Harty BJ, Mena O, Krous HF, Kinney HC. Serotonin metabolites in the cerebrospinal fluid in the sudden infant death syndrome: In search of a biomarker of risk.  J Neuropathol Exp Neurol 2014; 73: 115-22.
  2. Kinney HC, Cryan, JB, Haynes RL, Paterson DS, Haas EA, Mena OJ, Minter M, Journey KW, Trachtenberg FL, Goldstein RD, Armstrong DD. Dentate gyrus abnormalities in sudden unexplained death in infants: Morphological marker of underlying brain vulnerability.  Acta Neuropathol 2015; 65-80.
  3. Bianciardi M, Toschi N, Edlow BL, Eichner C, Sestompop K, Polimeni JR, Kinney HC, Rosen BR, Wald LL. In vivo neuroimaging template of human brainstem nuclei. Brain Connect 2015 Aug 11 [Epub ahead of print].
  4. Edlow BL, McNab JA, Witzel T, Kinney HC. The structural connectome of the human central homeostatic network. Brain Connect 2016; 6: 187-200.
  5. Hefti MM, Cryan JB, Grafe M, Haas EA, Chadwick AE, Crandall LA, Trachtenberg FL, Kinney HC, Krous HF. Part 1. Sudden unexpected death in early childhood: A series of 151 cases. Forensic Sci Med Pathol 2016; 12; 4-13.
  6. Hefti MM, Cryan JB, Haas EA, Chadwick AE, Crandall LA, Trachtenberg FL, Armstrong DD, Grafe M, Krous F, Kinney HC. Part II. Sudden unexpected death in early childhood: Neuropathologic observations. Forensic Sci Med Pathol 2016; 12; 14-25.
  7. Goldstein RD, Trachtenberg FL, Sens MA, Harty B, Kinney HC. SIDS and infant mortality rates.  Pediatrics 2016; 137: 1-10.
  8. Kinney HC*, Poduri AH* (*, co-first authors), Cryan JB, Haynes RL, Teot L, Sleeper LA, Holm IA, Berry GT, Prabhu, Warfield SK, Brownstein CA, Abram HS, Kruer M, Kemp, WL, Hargitai B, Gastrang J, Mena OJ, Haas EA, Dastjerdi, Armstrong DD, Goldstein, RG. Hippocampal formation maldevelopment and sudden death across the pediatric age spectrum. J Neuropathol Exp Neurol 2016; 75: 984-997.
  9. Haynes RL, Frelinger AL, Kozakewich HW, Tran H, Haas EA, Mena OJ, Trachtenberg FL, Berry GT, Michelson A, Goldstein RD, Kinney, HC. Elevated serum serotonin in a large subset of infants dying of the sudden infant death syndrome.  Under review, 2016.
  10. Goldstein RD, Nields HM, Holm IA, Poduri AH, Morris SE, Brownstein CA, Teot L, Berry GT, Warfield SK, Prabhu SP, Haynes RL, Gilles EK, MacRae CA, Dymecki SM, Kinney HC. A new paradigm for the investigation of sudden unexpected death in young children.  Under review, 2016.
  11. Brownstein CA, Goldstein RD, Kinney HC, Haynes RL, Giles E, Sheidley B, Bainbridge M, Haas EA, Lucas J, Schaber B, Holm IA, Poduri AH. SCN1A associated with two cases of sudden infant death syndrome.  Under review, 2016.

 

The Safe Passage Study: Dr. Kinney is  the Principal Investigator of the Developmental Brain and Pathology Center, and member of the Steering Committee of the PASS Network and Safe Passage Study, a NIH-funded consortium to study the effects of prenatal alcohol exposure upon morbidity and mortality of the human fetus and infant.  Dr. Haynes is the Co-Principal Investigator of the DBPC and member of the Steering Committee.

 

  1. Dukes KA, Burd L, Elliott AJ, Fifer WP, Folkerth RD, Hankins GD, Hereld D, Hoffman H, Myers MM, Odendaal HJ, Signore C, Sullivan LM, Willinger M, Wright C, and Kinney HC for the PASS Network. The Safe Passage Study: Design, Methods, Recruitment, and Follow-Up Approach. Pediatr Perinat Epi 2014, Aug 5 [Epub ahead of print].
  2. Human M, Green S, Groenwald C, Goldstein RD, Kinney HC, Odendaal HJ, PASS Network. Psychosocial implications of stillbirth for the mother and her family: A crisis support approach. Social Work (Stellenbosch) 2015; 50: 392.
  3. Boyd TK, Wright CA, Odendall HJ, Sens MA, Folkerth RD, Roberts DJ, Kinney HC, for the PASS Network. The stillbirth classification system for the Safe Passage Study: Incorporating mechanism, etiology, and recurrence. Pediatr Dev Pathol 2016 April 26 [Epub ahead of print].
  4. Dempers JJ, Coldrey J, Burger EH, Thompson V, Wadee SA, Odendaal HJ, Sens MA, Randall BB, Folkerth RD, Kinney HC for the PASS Network. The institution of standardized investigation protocol for sudden infant death in the Eastern Metropole, Cape Town, South Africa. J Forensic Sci 2016, Sept 27 [Epub ahead of print].
  5. Haynes RL, Folkerth RD, Paterson DS, Broadbelt KG, Dan Zaharie S, Hewlett RH, Dempers JJ, Burger E, Wadee S, Schubert P, Wright C, Sens MA, Nelsen L, Randall BB, Tran H, Geldenhuys E, Elliott AJ, Odendaal HJ, Kinney HC; PASS Network. Serotonin receptors in the medulla oblongata of the human fetus and infant: The analytic approach of the international Safe Passage Study. J Neuropathol Exp Neurol. 2016 Sep 15. pii: nlw080.

 

Proceedings of Meetings

 

  1. Goldstein RD, Kinney HC, Willinger MW. Special Article: Sudden unexpected death in fetal life through early childhood: New opportunities (Proceedings of an NICHD Workshop). Pediatrics 2016; 137.

 

Chapter in Book

 

  1. Kinney HC, Heft MM, Goldstein RD, Haynes RL. The Sudden Infant Death Syndrome.  In:  Golden JA, Harding BN (eds). Pathology and Genetics: Acquired and Inherited Diseases of the Developing Nervous System. Basel: ISN Neuropathology Press. 2016, in press.

 

Technical and Other Scientific Interventions

 

  1. Edlow, BL, Folkerth RD, Kinney HC. 2016. The Harvard Ascending Arousal Network (AAN) Atlas. Neuroanatomic atlas of brainstem nuclei of the human AAN in standard MNI152 space for neuroimaging, including diffusion tractography. Available to the academic community

(www.martinos.org/resources/aan-atlas) to enable structural and functional connectivity analyses of the human AAN in healthy subjects and in patients with disorders of consciousness.